研究業績

学術論文

2025年

• The Therapeutic Potential of Plant-Derived Flavonoids in Neurological Disorders Through Modulation of Brain Insulin Signaling
  Parida, I.S., Rahmania, H., Nakagawa, K.
  Food Sci. Technol. Res. 31 (2025).

2024年

• Impact of selenium content in fetal bovine serum on ferroptosis susceptibility and selenoprotein expression in cultured cells
  Takashima, H., Toyama, T.*, Mishima, E., Ishida, K., Wang, Y., Ichikawa, A., Ito, J., Yogiashi, S., Siu, S., Sugawara, M., Shiina, S., Arisawa, K., Conrad, M., Saito, S.*
  J. Toxicol. Sci. 49, 555-563 (2024).
• Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria
  Hirata Y*, Yamada Y, Taguchi S, Kojima R, Masumoto H, Kimura S, Niijima T, Toyama T, Kise R, Sato E, Uchida Y, Ito J, Nakagawa K, Taguchi T, Inoue A, Saito Y, Noguchi T, Matsuzawa A.*
  Cell Death Dis. 15, 884 (2024).
• PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization
  Ito, J., Nakamura, T., Toyama, T., Chen, D., Berndt, C., Poschmann, G., Mour_o, A. S. D., Doll, S, Suzuki, M., Zhang, W., Zheng, J., Tr_mbach, D., Yamada, N., Ono, K., Yazaki, M., Kawai, Y., Arisawa, M., Ohsaki, Y., Shirakawa, H., Wahida, A., Proneth, B., Saito, Y., Nakagawa, K., Mishima, E., Conrad, M.
  Mol. Cell. (2024).
• Nondestructive determination of canola oil oxidation causes: A near-infrared spectroscopy coupled with liquid chromatography-mass spectrometry for analyzing triacylglycerol hydroperoxide isomers
  Otoki, Y., Ishikawa, D., Kato, S., Kusumoto, I., Ozaki, Y., Nakagawa, K.
  Food Chem. (2024).
• Oil polyunsaturated fatty acid composition but not tocopherol levels determine oxylipin formation in plant and algae oils during pan-frying
  Kusumoto, I., Hennebelle, M., Crawford, L. M., Wang, S. C., Taha, A. Y.
  J. Food Compos. Anal. (2024).
• Mechanism of lipid peroxidation of liposomes by cold atmospheric pressure plasma jet irradiation
  Takajo, T., Saito, K., Tsuchida, K., Kato, S., Nakagawa, K., Okino, A., Anzai, K.
  J. Clin. Biochem. Nutr. (2024).
• 1-Deoxynojirimycin attenuates pathological markers of Alzheimer's disease in the in vitro model of neuronal insulin resistance
  Parida, I.S., Takasu, S., Ito, J., Eitsuka, T., Nakagawa, K.*
  FASEB J. (2024).
• Effects of different manufacturing processes on thermal and photo-oxidative stability of sesame oil
  Rahmania, H., Nakanishi, T., Oi, S., Onishi, R., Yamagami, E., Yamane,K., Otoki, Y., Kato, S., Nakagawa, K.
  J. Oleo Sci. (2024).
• Intraperitoneally injected d11-11(12)-epoxyeicosatrienoic acid is rapidly incorporated and esterified within rat plasma and peripheral tissues but not the brain
  Watanabe, S., Souza, F. D. C., Kusumoto, I., Shen, Q., Nitin, N., Lein, P. J., Taha, A. Y.
  Prostaglandins, Leukot. Essent. Fat. Acids, 102622 (2024).
• Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
  Yamada, N.#*, Karasawa, T.#*, Ito, J., Yamamuro, D., Morimoto, K., Nakamura, T., Komada, T., Baatarjav, C., Saimoto, Y., Jinnouchi, Y., Watanabe, K., Miura, K., Yahagi, Y., Nakagawa, K., Matsumura, T., Yamada, K., Ishibashi, S., Sata, N., Conrad M., Takahashi, M.*
  Nat. Commun. 15, 2195 (2024).
• A tangible method to assess native ferroptosis suppressor activity
  Nakamura, T.#, Ito, J.#, Mour_o, A.S.D., Wahida, A., Nakagawa, K., Mishima, E.*, Conrad, M.*
  Cell Rep. Methods 4, 100710 (2024).
• Identification of genes associated with resistance to persulcatusin, a tick defensin from Ixodes persulcatus
  Shimoda, S., Ito, J., Ando, T., Tobe, R., Nakagawa, K., Yoneyama, H.*
  Microorganisms 12, 412 (2024).
• Induction of ferroptosis in human keratinocyte HaCaT cells by squalene hydroperoxide: Possible prevention of skin ferroptosis by botanical extracts
  Kato, C., Kusumoto, I., Kato, S., Otoki, Y., Ito, J., Totsuka, H., Rajgopal, A., Hong, J., Nakagawa, K.*
  Biochem. Biophys. Res. Commun. 698, 149553 (2024).
• Comparison of the catabolic rates of linoleic and oleic acid hydroperoxides using 13CO2 expired from mice
  Yoshinaga-Kiriake, A., Miyagawa, S., Yoshino, K., Tanaka, S., Yoshinaga, K., Takahashi, T., Kato, S., Ito, J., Yurika, O., Nakagawa, K., Gotoh, N.*
  J. Oleo Sci. (2024).
• Preparation of saturated fatty acid hydroperoxide isomers and determination of their thermal decomposition products _ 2-alkanones and lactones
  Aoyagi, K., Kato, S., Isaka, D., Sekiguchi, Y., Otoki, Y., Uehara, H., Nakagawa, K.*
  Food Chem. X 21, 101074 (2024).
• Higher Cholesterol Absorption Marker at Baseline Predicts Fewer Cardiovascular Events in Elderly Patients Receiving Hypercholesterolemia Treatment: The Kyushu Elderly Ezetimibe Phytosterol (KEEP) Study
  Kuwabara, M., Sasaki, J., Ouchi, Y., Oikawa, S., Nakagawa, K., Sato, M., Koba, S., Kono, S., Saikawa, T., Arai, H.*
  J. Am. Heart Assoc. 13, e03165 (2024).
• LC-MS/MS analysis of milk triacylglycerol hydroperoxide isomers which are generated corresponding to the photo- and thermal-oxidation
  Saito, H., Kato, S., Shimizu, N., Takahashi, T., Jutanom, M., Ito, J., Kasatani, S., Nakagawa, K.*
  Food Res. Int. 178, 113913 (2024).

2023年

• Analysis of oxidized glucosylceramide and its effects on altering gene expressions of inflammation induced by LPS in intestinal tract cell models
  Jutanom, M., Kato, S., Yamashita, S., Toda, M., Kinoshita, M., Nakagawa, K.*
  Sci. Rep. 13, 22537 (2023).
• Unveiling an unexpected superoxide-mediated photooxidation mechanism of squalene monohydroperoxides to squalene hydroperoxy cyclic peroxides through ESR and LC_MS/MS analyses
  Khalifa, S., Enomoto, M., Nakagawa, K.*
  Sci. Rep. 13, 19525 (2023).
• Sheep-derived cell immortalization through the expression of cell cycle regulators and biological characterization using transcriptomes
  Kikuchi, N., Matsusaka, H., Bai, L., Sano, H., Eitsuka, T., Nakagawa, K., Sugano, E., Ozaki, T., Tomita, H., Kiyono, T., Fukuda, T.*
  Cell Biol. Int. (2023).
• The difference in the cellular uptake of tocopherol and tocotrienol is influenced by their affinities to albumin
  Nakatomi, T., Itaya-Takahashi, M., Horikoshi, Y., Shimizu, N., Parida, I.S., Jutanom, M., Eitsuka, T., Tanaka, Y., Zingg, J.-M., Matsura, T., Nakagawa K.*
  Sci. Rep. 13, 7392 (2023).
• Expression and functional analyses for estrogen receptor and estrogen related receptor of Yesso scallop, Patinopecten yessoensis
  Gu, W., Thitiphuree, T., Otoki, Y., Marquez, E.C., Kitano, T., Itoh, N., Nagasawa, K., Osada, M.
  J. Steroid Biochem. Mol., 106302 (2023).
• Immortalization of primary cells derived from the endangered Ryukyu long-furred rat
  Bai, L., Kikuchi, N., Eitsuka, T., Matsusaka, H., Nakagawa, K., Katayama, M., Ito, K., Inoue-Murayama, M., Kiyono,T., Fukuda, T.*
  In Vitro Cellular & Developmental Biology - Animal 59, 224-233 (2023).
• ホヤ由来エタノールアミン型プラズマローゲンの認知機能に対する有効性及び安全性評価―プラセボ対照ランダム化二重盲検並行群間比較―
  山本采佳*, 相澤光輝, 久保村大樹, 赤堀雄介, 山下慎司, 仲川清隆, 宮澤陽夫
  応用薬理 104, 17-24 (2023).
• コーヒーシルバースキンに含まれる3-ピリジノールの単離精製とメラニン産生に及ぼす影響
  渡辺章夫, 衛藤未侑, 小山彩華, 要害心, 保永陽依, 前原一葉, 宮本京香, 加藤毅, 三嶋隆, 仲川清隆
  十文字大学紀要 53, 29-36 (2023).
• Quantitative lipidomic analysis of serum phospholipids reveals dissociable markers of Alzheimer disease and subcortical cerebrovascular disease
  Otoki, Y., Yu, D., Shen, Q., Sahlas, D.J., Ramirez, J., Gao, F., Masellis, M., Swartz, R.H., Chan, P.C., Pettersen, J.A., Kato, S., Nakagawa, K., Black, S.E., Swardfager, W., Taha, A.T.*
  J. Alzheimer's Dis. 93, 665-682 (2023).
• Effects of particle size of curcumin solid dispersions on bioavailability and anti-inflammatory activities
  Kato, C., Itaya-Takahashi, M., Miyazawa, T., Ito, J., Parida, I.S., Yamada, H., Abe, A., Shibata, M., Someya, K., Nakagawa,K.*
  Antioxidants 12, 724 (2023).
• Elucidation of decomposition pathways of linoleic acid hydroperoxide isomers by GC-MS and LC-MS/MS
  Miyazaki, R., Kato, S., Otoki, Y., Rahmania, H., Sakaino, M., Takeuchi, S., Sato, T., Imagi, J., Nakagawa, K.*
  Biosci. Biotechnol. Biochem. 87, 179-190 (2023).
• Clinical evaluation based on a new approach to improve the accuracy of 4β-hydroxycholesterol measurement as a biomarker of CYP3A4 activity
  Taya, Y. Mizunaga, M., Nakao, S., Jutanom, M., Shimizu, N., Nomura, Y., Nakagawa,K.*
  Molecules 28, 1576 (2023).
• Analysis of docosahexaenoic acid hydroperoxide isomers in mackerel using liquid chromatography_mass spectrometry
  Kusumoto, I., Kato, S., Nakagawa, K.*
  Sci. Rep. 13, 1325 (2023).

2022年

• Evidence of increased sequestration of pro-resolving lipid mediators within brain esterified lipid pools of multiple sclerosis patients
  Shen, Q., Otoki, Y., Sobel, R.A., Nagra, R.M., Taha, A.Y.*
  Mult . Scler. Relat. Disord. 68, 104236 (2022).
• Structural analysis and anti-inflammatory effect of a digalactosyldiacylglycerol-monoestolide, a characteristic glycolipid in oats
  Yamada, H., Ito, J., Shimizu, N., Takahashi, T., Kato, C., Parida, I.S., Jutanom, M., Ishihara, K., Nakagawa,K.*
  Nutrients 14, 4153 (2022).
• Coprinopsis cinerea dioxygenase is an oxygenase forming 10(S)-hydroperoxide of linoleic acid, essential for mushroom alcohol, 1-octen-3-ol synthesis
  Teshima, T., Funai, R., Nakazawa, T., Ito, J., Utsumi, T., Kakumyan, P., Mukai, H., Yoshiga, T., Murakami, R., Nakagawa, K., Honda, Y., Matsui, K.*
  J. Biol. Chem. 298, 102507 (2022).
• Dietary triacylglycerol hydroperoxide is not absorbed, yet it induces the formation of other triacylglycerol hydroperoxides in the gastrointestinal tract
  Takahashi, T., Kato, S., Ito, J., Shimizu, N., Parida, I.S., Itaya-Takahashi, M., Sakaino, M., Imagi, J., Yoshinaga, K., Yoshinaga-Kiriake, A., Gotoh, N., Ikeda. I., Nakagawa, K.*
  Redox. Biol. 57, 102471 (2022).
• Possible Glutathione Peroxidase 4-Independent Reduction of Phosphatidylcholine Hydroperoxide: Its Relevance to Ferroptosis
  Kato, C., Suzuki, Y., Parida, I.S., Kato, S., Yamasaki, H., Takekoshi, S., Nakagawa, K.*
  J. Oleo Sci. 71, 1689-1694 (2022).
• Cellular uptake of pyrroloquinoline quinone in its intact and derivatized forms from the cell culture medium of 3T3-L1
  Kato, C., Parida, I.S., Maeda, S., Mikekado, T., Kato, S., Takekoshi, S., Nakagawa, K.*
  J. Oleo Sci. 71, 1761-1767 (2022).
• A non-canonical vitamin K cycle is a potent ferroptosis suppressor
  Mishima, E.*, Ito, J., Wu, Z., Nakamura, T., Wahida, A., Doll, S., Tonnus, W., Nepachalovich, P., Eggenhofer E., Aldrovandi, M., Henkelmann, B., Yamada, K., Wanninger, J., Zilka, O., Sato, E., Feederle, R., Hass, D., Maida, A., Mour_o, A.S.D., Linkermann, A., Geissler, E.K., Nakagawa, K., Abe, T., Fedorova, M., Proneth, B., Pratt, D.A., Conrad, M.*
  Nature 608, 778-783 (2022).
• Determination of olive oil oxidation mechanisms by analysis of triacylglycerol hydroperoxide isomers using LC-MS/MS
  Takahashi, H., Kato, S., Shimizu, N., Otoki, Y., Ito, J., Sakaino, M., Sano, T., Imagi, J., Nakagawa, K.*
  Molecules 27, 5282 (2022).
• Carboxylic acids derived from triacylglycerols that contribute to the increase in acid value during the thermal oxidation of oils
  Sakaino, M., Sano, T., Kato, S., Shimizu, N., Ito, J., Rahmania, H., Imagi, J., Nakagawa, K.*
  Sci. Rep. 12, 12460 (2022).
• Total synthesis of the broad-spectrum antibiotic amycolamicin
  Meguro, Y., Ito, J., Nakagawa, K., Kuwahara, S.*
  J. Am. Chem. Soc. 144, 5253-5257 (2022).
• Improving water dispersibility and bioavailability of luteolin using microemulsion system
  Miyashita, A., Ito, J., Parida, I.S., Syoji, N., Fujii, T., Takahashi, H., Nakagawa, K.*
  Sci. Rep. 12, 11949 (2022).
• Immortalization of common marmoset-derived fibroblasts via expression of cell cycle regulators using the piggyBac transposon
  Orimoto, A.*, Shinohara, H. Eitsuka, T., Nakagawa, K., Sasaki, E., Kiyono, T.*, Fukuda, T.*
  Tissue Cell 77, 101848 (2022).
• Cellular concentrations of plasmalogen species containing a polyunsaturated fatty acid significantly increase under hypoxia in human colorectal cancer, Caco2 cells
  Tamiya-Koizumi, K., Otoki, Y., Nakagawa, K., Kannagi, R., Mizutani, N., Suzuki, M., Kyogashima, M., Iwaki, S., Aoyama, M., Murate, T., Kitatani, K., Kuga, T., Mizutani, Y., Tokumura, A.*
  Biochem. Biophys. Res. Commun. 611, 1-7 (2022).
• Effects of hypercapnia / ischemia and dissection on the rat brain metabolome
  Sylvestre, D.A., Otoki, Y., Metherel, A.H., Bazinet, R.P., Slupsky, C.M. Taha. A.Y.*
  Neurochem. Int. 156, 105294 (2022).
• Determination of acrolein generation pathways from linoleic acid and linolenic acid: increment by photo irradiation
  Kato, S., Shimizu, N., Otoki, Y., Ito, J., Sakaino, M. Sano, T., Takeuchi, S., Imagi, J., Nakagawa, K.*
  npj Sci. Food 6, 21 (2022).
• Lipidomics and redox lipidomics indicate early-stage alcohol-induced liver damage
  Koelmel, J.P., Tan, W.Y., Li, Y., Bowden, J.A., Ahmadireskety, A., Patt, A.C., Orlicky, D.J., Math_, E., Kroeger, N.M., Thompson, D.C., Cochran, J.A., Golla, J.P., Kandyliari, A., Chen, Y., Charkoftaki, G., Guingab-Cagmat, J.D., Tsugawa, H., Arora, A., Veselkov, K., Kato, S., Otoki, Y., Nakagawa, K., Yost, R.A., Garrett, T.J.*, Vasilou, V.*
  Hepatol. Commun. 6, 513-525 (2022).
• The inhibition of interaction with serum albumin enhances the physiological activity of curcumin by increasing its cellular uptake
  Itaya, M., Miyazawa, T., Khalifa, S., Shimizu N., Nakagawa, K.*
  Food Funct. 13, 639-648 (2022).