研究業績

国際学会（一般講演）

2026年

• Integrated LC–MS/MS Lipidomics of PUFA-Phospholipids and PL-Bound Oxylipins Links Brain Lipid Remodeling to Cognitive Function in Alzheimer’s Disease

  Yurika Otoki, Kiyotaka Nakagawa, Shunji Kato

  2026 AOCS Annual Meeting & Expo. (New Orleans, 2026/5/3-6)
• Photo-oxidation of plant-based milk alternatives and cow milk: Effects on lipid oxidation products, volatile compounds and sensory properties.

  Satoshi Kasatani, Tsutashi Matsuura, Kiyotaka Nakagawa, Junya Ito, Naoya Irisawa

  2026 AOCS Annual Meeting & Expo. (New Orleans, 2026/5/3-6)
• Development of a novel near-infrared spectroscopy framework for continuous assessment and future prediction of lipid oxidation in extra virgin olive oil

  Ibuki Kusumoto, Shunji Kato, Daitaro Ishikawa, Yurika Otoki, Yukihiro Ozaki, Kiyotaka Nakagawa

  2026 AOCS Annual Meeting & Expo. (New Orleans, 2026/5/3-6)
• Study of the acidic compounds derived from triacylglycerol that contribute to acid value increment

  Ryosuke Aoki, Shunji Kato, Masayoshi Sakaino, Jun Imagi, Toshiro Sato, Kiyotaka Nakagawa

  2026 AOCS Annual Meeting & Expo. (New Orleans, 2026/5/3-6)
• Mechanistic Elucidation of Saturated Fatty Acid Oxidation by GC-MS and LC-MS/MS

  Shunji Kato, Kanji Aoyagi, Yurika Otoki, Kiyotaka Nakagawa

  2026 AOCS Annual Meeting & Expo. (New Orleans, 2026/5/3-6)
• Elucidating the antioxidative mechanism of blending rice bran oil at ambient temperature

  Shota Koishi, Sari Honda, Midori Matsuki, Kazue Sawada, Hiroyuki Hashimoto, Yuki Kadono, Halida Rahmania, Yurika Otoki, Shunji Kato, Kiyotaka Nakagawa

  2026 AOCS Annual Meeting & Expo. (New Orleans, 2026/5/3-6)
• Discrimination of positional isomers of hydroxy fatty acids by electron activated dissociation and application to dairy sample analysis

  Kai Nakayama, Junya Ito, Kiyotaka Nakagawa

  2026 AOCS Annual Meeting & Expo. (New Orleans, 2026/5/3-6)
• Analysis of γ-oryzanol molecules in rice bran oil: Elucidation of novel γ-oryzanol species

  Kazue Sawada, Takuya Nakagami, Midori Matsuki, Junya Ito, Yusuke Ogura, Hiroyuki Hashimoto, Kiyotaka Nakagawa

  2026 AOCS Annual Meeting & Expo. (New Orleans, 2026/5/3-6)

2025年

• Explore the selenium metabolic pathway involved in methylmercury sensitivity

  Hayato Takashima, Hiroki Taguchi, Takashi Toyama, Junya Ito, Eikan Mishima, Yoshiro Saito

  The Joint Meeting of 8th Japanese Selenium Research Society
  and 13th International Symposium on Selenium in Biology and Medicine (Se2025)（Sendai, 2025/10/30-11/2）
• Mechanism of arsenic-induced disruption of selenium metabolism and the role of PRDX6 in ferroptosis susceptibility

  Reiko Makino, Hayato Takashima, Takashi Toyama, Junya Ito, Eikan Mishima, Marcus Conrad, Yoshiro Saito

  The Joint Meeting of 8th Japanese Selenium Research Society
  and 13th International Symposium on Selenium in Biology and Medicine (Se2025)（Sendai, 2025/10/30-11/2）
• Identification of PRDX6 as a cellular selenium acceptor protein

  Junya Ito, Toshitaka Nakamura, Takashi Toyama, Carsten Berndt, Gereon Poschmann, Yoshiro Saito, Kiyotaka Nakagawa, Eikan Mishima, Marcus Conrad

  The Joint Meeting of 8th Japanese Selenium Research Society
  and 13th International Symposium on Selenium in Biology and Medicine (Se2025)（Sendai, 2025/10/30-11/2）
• Direct analysis of esterified docosahexaenoic acid hydroperoxide isomers in biological systems with liquid chromatography-tandem mass spectrometry

  Ibuki Kusumoto, Shunji Kato, Kiyotaka Nakagawa

  23rd International Congress of Nutrition of the International Union of Nutritional Sciences (IUNS-ICN 2025)（Paris, 2025/08/24-29）
• Development of a highly accurate analytical method for PQQ in foods using LC-MS/MS

  Yoshinari Hirakawa, Chikara Kato, Takashi Mishima, Kiyotaka Nakagawa

  2025 AOAC ANNUAL MEETING & EXP. (San Diego, 2025/08/23-28)
• Involvement of Peroxiredoxin 6 in disturbance of selenium metabolism and ferroptosis sensitivity by methylmercury

  Hayato Takashima, Takashi Toyama, Junya Ito, Eikan Mishima, Yoshiro Saito

  Redox Week in Sendai 2025 (Sendai, 2025/04/17-21)
• Improvement of total choline analytical method and reevaluation of daily intake

  Yoshinari Hirakawa, Kiyotaka Nakagawa

  2025 AOCS Annual Meeting & Expo. (Portland, 2025/04/27-30)
• Development of direct analytical methods for esterified docosahexaenoic acid hydroperoxide in food and biological systems using liquid chromatography-mass spectrometry

  Ibuki Kusumoto, Shunji Kato, Kiyotaka Nakagawa

  2025 AOCS Annual Meeting & Expo. (Portland, 2025/04/27-30)
• The mechanism of 2-alkanone and lactone formation by thermal oxidation of saturated fatty acids

  Daisuke Isaka, Kanji Aoyagi, Shunji Kato, Yurika Otoki, Hidetaka Uehara, Kiyotaka Nakagawa

  2025 AOCS Annual Meeting & Expo. (Portland, 2025/04/27-30)
• Study of the acidic compounds derived from triacylglycerol that contribute to acid value increment

  Ryosuke Aoki, Shunji Kato, Masayoshi Sakaino, Toshiro Sato, Jun Imagi, Kiyotaka Nakagawa

  2025 AOCS Annual Meeting & Expo. (Portland, 2025/04/27-30)
• Comparison of diacylglycerol and triacylglycerol lipid oxidation through LC-MS/MS analysis of hydroperoxide isomers

  Mizue Ouchi, Katsuyoshi Saitou, Masao Shimizu, Shunji Kato, Kiyotaka Nakagawa

  2025 AOCS Annual Meeting & Expo. (Portland, 2025/04/27-30)

2024年

• Effect of water activity on the oxidative stability of fats and oils

  Tomoyuki Takada, Shunji Kato, Yurika Otoki, Tomoyuki Fujii, Daitaro Ishikawa, Kiyotaka Nakagawa

  International Symposium on Designing Foods for the Future（Sendai, 2024/9/19-21）
• Generation of volatile compounds via the oxidation of squalene in shark liver oil

  Rira Wakayama, Junya Ito, Naoki Shimizu, Kiyotaka Nakagawa

  International Symposium on Designing Foods for the Future（Sendai, 2024/9/19-21）
• Lipid oxidation in meat induced by photoirradiation

  Sayaka Chida, Shunji Kato, Kiyotaka Nakagawa

  International Symposium on Designing Foods for the Future（Sendai, 2024/9/19-21）
• Analysis of a unique linoleic acid hydroperoxide isomer formed during oxidation in the presence of α-tocopherol

  Yuki Kadono, Shunji Kato, Kiyotaka Nakagawa

  International Symposium on Designing Foods for the Future（Sendai, 2024/9/19-21）
• Removal of Secondary Oxidation Products in Fish Oil During Storage by Polyamine Resin

  Yonglin Xia, Shunji Kato, Kiyotaka Nakagawa

  International Symposium on Designing Foods for the Future（Sendai, 2024/9/19-21）
• Deciphering the difference of absorption of epicatechins and non-epicatechins in human and rat

  Aldila Akmal Mahdi, Ayaka Miyashita, Junya Ito, Ikuo Ikeda, Kiyotaka Nakagawa

  International Symposium on Designing Foods for the Future（Sendai, 2024/9/19-21）
• Analyzing hydroperoxyl positions of esterified docosahexaenoic acid hydroperoxide with liquid chromatography-tandem mass spectrometry

  Ibuki Kusumoto, Shunji Kato, Kiyotaka Nakagawa

  International Symposium on Designing Foods for the Future（Sendai, 2024/9/19-21）
• Comprehensive analysis of ferroptosis-related gene expression in phosphatidylcholine hydroperoxide-treated HepG2 human hepatocarcinoma cells

  Daisuke Sato, Chikara Kato, Junya Ito, Takahiro Eitsuka, Kiyotaka Nakagawa

  International Symposium on Designing Foods for the Future（Sendai, 2024/9/19-21）
• Assessment of triacylglycerol hydroperoxide absorption and metabolism using liquid chromatography-mass spectrometry

  Riko Tawaraya, Takumi Takahashi, Shunji Kato, Junya Ito, Yurika Otoki, Kiyotaka Nakagawa

  International Symposium on Designing Foods for the Future（Sendai, 2024/9/19-21）
• Exploring the quenching mechanism of plasmalogens in response to singlet oxygen

  Natsuki Watanabe, Yurika Otoki, Shunji Kato, Kiyotaka Nakagawa

  International Symposium on Designing Foods for the Future（Sendai, 2024/9/19-21）
• Effect of vitamin E on ferroptosis

  Yang Hao, Junya Ito, Eikan Mishima, Kiyotaka Nakagawa

  International Symposium on Designing Foods for the Future（Sendai, 2024/9/19-21）
• Direct analysis of esterified docosahexaenoic acid oxidation products with liquid chromatography-tandem mass spectrometry

  Ibuki Kusumoto, Shunji Kato, Kiyotaka Nakagawa

  International Conference on Food Safety & Regulatory Measures (Web (Dublin), 2024/12/16)

2023年

• Effects of dietary whey protein phospholipid concentrate from milk on circulating lipid mediators and memory in rats

  Ibuki Kusumoto, Duncan Sylvestre, Daniela Barile, Ameer Taha

  International Society for the Study of Fatty Acids 2023 Congress（Nantes, 2023/7/2-5）
• Characterization of antimicrobial resistance in Staphylococcus aureus against tick defensin "persulcatusin" from hard tick Ixodes persulcatus

  So Shimoda, Junya Ito, Kiyotaka Nakagawa, Tasuke Ando, Ryuta Tobe, Hiroshi Yoneyama

  ASM Microbe 2023 (Houston, 2023/7/15-19)
• Lipid oxidation stress: Botanical anthioxidant strategies for health

  Kiyotaka Nakagawa, Jina Hong, Arun Rajgopal, Hirono Totsuka, Junya Ito, Shunji Kato, Takahiro Eitsuka

  14th Asian Congress of Nutrition（China, 2023/9/14-17）
• Removal of secondary oxidation products in oxidized edible oil by polyamine resin

  Yonglin Xia, Shunji Kato, Tadashi Adachi, Kiyotaka Nakagawa

  14th Asian Congress of Nutrition（China, 2023/9/14-17）

2022年

• Analyzing hydroperoxyl positions of esterified docosahexaenoic acid hydroperoxide with liquid chromatography-tandem mass spectrometry

  Ibuki Kusumoto, Shunji Kato, Kiyotaka Nakagawa

  The 2nd World Congress on Oleo Science（Web, 2022/8/23-9/3）
• Evaluation system for oxidation of milk lipids with LC-MS/MS

  Hirotada Saito, Junya Ito, Shunji Kato, Satoshi Kasatani, Kiyotaka Nakagawa

  The 2nd World Congress on Oleo Science（Web, 2022/8/23-9/3）
• Oxidative stability comparison of edible oils under thermal and photo-oxidation

  Halida Rahmania, Shota Koishi, Ryunoshin Kono, Shigeo Nakajima, Yurika Otoki, Shunji Kato, Kiyotaka Nakagawa

  The 2nd World Congress on Oleo Science（Web, 2022/8/23-9/3）
• The particle size of the curcumin dispersion is important for the expression of the anti-inflammatory effect of curcumin

  Chihiro Kato, Mayuko Itaya-Takahashi, Taiki Miyazawa, Hiroki Yamada, Keita Someya, Mika Shibata, Akari Abe, Kiyotaka Nakagawa

  The 2nd World Congress on Oleo Science（Web, 2022/8/23-9/3）
• Determination of acrolein generation pathways from linoleic acid and linolenic acid: Increment by photo irradiation

  Shunji Kato, Naoki Shimizu, Yurika Otoki, Junya Ito, Masayoshi Sakaino, Takashi Sano, Shigeo Takeuchi, Jun Imagi, Kiyotaka Nakagawa

  The 2nd World Congress on Oleo Science（Web, 2022/8/23-9/3）
• A non-canonical vitamin K cycle is a potent ferroptosis suppressor

  Eikan Mishima, Junya Ito, Toshitaka Nakamura, Bettina Proneth, Derek A. Pratt, Marcus Conrad

  Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease - CSH Asia（Awaji, 2022/10/10-14）
• Evaluation of lipid oxidation mechanisms using ion mobility mass spectrometry

  Junya Ito, Naoki Shimizu, Atsushi Hanada, Masamitsu Maekawa, Kiyotaka Nakagawa

  Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease - CSH Asia（Awaji, 2022/10/10-14）
• A non-canonical vitamin K cycle is a potent ferroptosis suppressor

  Eikan Mishima, Junya Ito, Kiyotaka Nakagawa, Takaaki Abe, Marcus Conrad

  The 12th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide（Sendai, 2022/10/28-11/1）
• A non-canonical vitamin K cycle is a potent ferroptosis suppressor

  Eikan Mishima, Junya Ito, Kiyotaka Nakagawa, Takaaki Abe, Marcus Conrad

  4th International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine / Tohoku Forum of Creativity（Sendai, 2022/10/28-11/1）
• The difference in the cellular uptake of tocopherols and tocotrienols is influenced by their affinity to albumin

  Takashi Nakatomi, Mayuko Itaya-Takahashi, Yosuke Horikoshi, Takahiro Eitsuka, Yoshikazu Tanaka, Tatsuya Matsura, Kiyotaka Nakagawa

  22nd IUNS-International Congress of Nutrition（Tokyo, 2022/12/6-11）
• Study on lactone formation by thermal oxidation of saturated fatty acids

  Kanji Aoyagi, Shunji Kato, Yurika Otoki, Kiyotaka Nakagawa

  22nd IUNS-International Congress of Nutrition（Tokyo, 2022/12/6-11）
• Bioactive iminosugar 1-deoxynojirimycin reverses neuronal insulin resistance and alleviates tau hyperphosphorylation: an in vitro study using insulin-resistant neuroblastoma

  Isabella Supardi Parida, Soo Takasu, Junya Ito, Takahiro Eitsuka, Kiyotaka Nakagawa

  22nd IUNS-International Congress of Nutrition（Tokyo, 2022/12/6-11）
• Discovery of novel human metabolites, dimethylated rosmarinic acids (DiMe-RAs), after oral intake of Perilla frutescens purpurea extract and their inhibitory activity on TRPV4

  Akihiro Takamura, Masazumi Iwashita, Eri Ozeki, Kohjiro Hashizume, Ryuta Shioi, Naoya Kitamura, Akihiro Fujii, Takatoshi Murase, Kiyotaka Nakagawa

  22nd IUNS-International Congress of Nutrition（Tokyo, 2022/12/6-11）
• The absorption and metabolism of γ-oryzanol, a functional compound characteristic of rice bran, is different depending on its molecular species

  Junya Ito, Yukiko Hayashi, Takumi Kokumai, Satoshi Maeda, Kazue Sawada, Hiroyuki Hashimoto, Kiyotaka Nakagawa

  22nd IUNS-International Congress of Nutrition（Tokyo, 2022/12/6-11）
• Water in oil emulsion system modifies absorption profile of green tea catechins in the body and also masks their bitter taste: Evaluation in human subjects

  Arata Hashimoto, Ayaka Miyashita, Junya Ito, Isabella Supardi Parida, Takashi Ichinose, Kiyotaka Nakagawa

  22nd IUNS-International Congress of Nutrition（Tokyo, 2022/12/6-11）
• Improvement of storage stability of vegetable oils by using rice bran oil

  Shota Koishi, Ami Okuda, Takahiro Inoue, Ryunoshin Kono, Shigeo Nakajima, Halida Rahmania, Yurika Otoki, Shunji Kato, Kiyotaka Nakagawa

  22nd IUNS-International Congress of Nutrition（Tokyo, 2022/12/6-11）
• Non-destructive analysis of lignan in sesame oil

  Yurika Otoki, Shiori Watanabe, Kenichi Miyazaki, Kiyotaka Nakagawa

  22nd IUNS-International Congress of Nutrition（Tokyo, 2022/12/6-11）
• Elucidation of novel γ-oryzanol species in rice bran oil and processed foods containing rice bran oil

  Kazue Sawada, Junya Ito, Yusuke Ogura, Hiroyuki Hashimoto, Kiyotaka Nakagawa

  22nd IUNS-International Congress of Nutrition（Tokyo, 2022/12/6-11）
• Study of the acidic compounds derived from triacylglycerol that contribute to acid value increment

  Masayoshi Sakaino, Takashi Sano, Shunji Kato, Naoki Shimizu, Junya Ito, Jun Imagi, Toshiro Sato, Kiyotaka Nakagawa

  22nd IUNS-International Congress of Nutrition（Tokyo, 2022/12/6-11）