2025年
受賞
学術論文
国内学会（招待講演、等）
国内学会（一般講演）
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玄米の長期摂取がヒト血漿中のγ-オリザノールに与える影響評価
小林由輝, 熊谷菜穂子, 山崎健治, 中畑弥子, 木下仁志, 松田辰志, 橋本博之, 紫籐治, 橋本道男, 伊藤隼哉, 仲川清隆
日本農芸化学会2025年度大会（札幌, 2025/3/4-8）
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国際学会（招待講演、等）
国際学会（一般講演）
2024年
受賞
学術論文
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Impact of selenium content in fetal bovine serum on ferroptosis susceptibility and selenoprotein expression in cultured cells
Takashima, H., Toyama, T.*, Mishima, E., Ishida, K., Wang, Y., Ichikawa, A., Ito, J., Yogiashi, S., Siu, S., Sugawara, M., Shiina, S., Arisawa, K., Conrad, M., Saito, S.*
J. Toxicol. Sci. 49, 555-563 (2024).
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Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria
Hirata Y*, Yamada Y, Taguchi S, Kojima R, Masumoto H, Kimura S, Niijima T, Toyama T, Kise R, Sato E, Uchida Y, Ito J, Nakagawa K, Taguchi T, Inoue A, Saito Y, Noguchi T, Matsuzawa A.*
Cell Death Dis. 15, 884 (2024).
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PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization
Ito, J., Nakamura, T., Toyama, T., Chen, D., Berndt, C., Poschmann, G., Mour_o, A. S. D., Doll, S, Suzuki, M., Zhang, W., Zheng, J., Tr_mbach, D., Yamada, N., Ono, K., Yazaki, M., Kawai, Y., Arisawa, M., Ohsaki, Y., Shirakawa, H., Wahida, A., Proneth, B., Saito, Y., Nakagawa, K., Mishima, E., Conrad, M.
Mol. Cell. (2024).
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Nondestructive determination of canola oil oxidation causes: A near-infrared spectroscopy coupled with liquid chromatography-mass spectrometry for analyzing triacylglycerol hydroperoxide isomers
Otoki, Y., Ishikawa, D., Kato, S., Kusumoto, I., Ozaki, Y., Nakagawa, K.
Food Chem. (2024).
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Mechanism of lipid peroxidation of liposomes by cold atmospheric pressure plasma jet irradiation
Takajo, T., Saito, K., Tsuchida, K., Kato, S., Nakagawa, K., Okino, A., Anzai, K.
J. Clin. Biochem. Nutr. (2024).
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Effects of different manufacturing processes on thermal and photo-oxidative stability of sesame oil
Rahmania, H., Nakanishi, T., Oi, S., Onishi, R., Yamagami, E., Yamane,K., Otoki, Y., Kato, S., Nakagawa, K.
J. Oleo Sci. (2024).
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Intraperitoneally injected d11-11(12)-epoxyeicosatrienoic acid is rapidly incorporated and esterified within rat plasma and peripheral tissues but not the brain
Watanabe, S., Souza, F. D. C., Kusumoto, I., Shen, Q., Nitin, N., Lein, P. J., Taha, A. Y.
Prostaglandins, Leukot. Essent. Fat. Acids, 102622 (2024).
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Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
Yamada, N.#*, Karasawa, T.#*, Ito, J., Yamamuro, D., Morimoto, K., Nakamura, T., Komada, T., Baatarjav, C., Saimoto, Y., Jinnouchi, Y., Watanabe, K., Miura, K., Yahagi, Y., Nakagawa, K., Matsumura, T., Yamada, K., Ishibashi, S., Sata, N., Conrad M., Takahashi, M.*
Nat. Commun. 15, 2195 (2024).
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A tangible method to assess native ferroptosis suppressor activity
Nakamura, T.#, Ito, J.#, Mour_o, A.S.D., Wahida, A., Nakagawa, K., Mishima, E.*, Conrad, M.*
Cell Rep. Methods 4, 100710 (2024).
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Identification of genes associated with resistance to persulcatusin, a tick defensin from Ixodes persulcatus
Shimoda, S., Ito, J., Ando, T., Tobe, R., Nakagawa, K., Yoneyama, H.*
Microorganisms 12, 412 (2024).
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Induction of ferroptosis in human keratinocyte HaCaT cells by squalene hydroperoxide: Possible prevention of skin ferroptosis by botanical extracts
Kato, C., Kusumoto, I., Kato, S., Otoki, Y., Ito, J., Totsuka, H., Rajgopal, A., Hong, J., Nakagawa, K.*
Biochem. Biophys. Res. Commun. 698, 149553 (2024).
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Comparison of the catabolic rates of linoleic and oleic acid hydroperoxides using 13CO2 expired from mice
Yoshinaga-Kiriake, A., Miyagawa, S., Yoshino, K., Tanaka, S., Yoshinaga, K., Takahashi, T., Kato, S., Ito, J., Yurika, O., Nakagawa, K., Gotoh, N.*
J. Oleo Sci. (2024).
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Preparation of saturated fatty acid hydroperoxide isomers and determination of their thermal decomposition products _ 2-alkanones and lactones
Aoyagi, K., Kato, S., Isaka, D., Sekiguchi, Y., Otoki, Y., Uehara, H., Nakagawa, K.*
Food Chem. X 21, 101074 (2024).
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Higher Cholesterol Absorption Marker at Baseline Predicts Fewer Cardiovascular Events in Elderly Patients Receiving Hypercholesterolemia Treatment: The Kyushu Elderly Ezetimibe Phytosterol (KEEP) Study
Kuwabara, M., Sasaki, J., Ouchi, Y., Oikawa, S., Nakagawa, K., Sato, M., Koba, S., Kono, S., Saikawa, T., Arai, H.*
J. Am. Heart Assoc. 13, e03165 (2024).
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LC-MS/MS analysis of milk triacylglycerol hydroperoxide isomers which are generated corresponding to the photo- and thermal-oxidation
Saito, H., Kato, S., Shimizu, N., Takahashi, T., Jutanom, M., Ito, J., Kasatani, S., Nakagawa, K.*
Food Res. Int. 178, 113913 (2024).
レビュー・書籍・プレス・その他
国内学会（招待講演、等）
国内学会（一般講演）
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過酸化スクアレンによるヒト皮膚角化細胞へのフェロトーシスの誘導と植物抽出物による抑制
加藤主税, 楠本惟吹, 加藤俊治, 乙木百合香, 伊藤隼哉, 鈴木優里, 戸塚広乃, Arun Rajgopal, Jina Hong, 仲川清隆
日本農芸化学会2024年度大会（東京, 2024/3/24-27）
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国際学会（招待講演、等）
国際学会（一般講演）
2023年
受賞
学術論文
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Analysis of oxidized glucosylceramide and its effects on altering gene expressions of inflammation induced by LPS in intestinal tract cell models
Jutanom, M., Kato, S., Yamashita, S., Toda, M., Kinoshita, M., Nakagawa, K.*
Sci. Rep. 13, 22537 (2023).
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Sheep-derived cell immortalization through the expression of cell cycle regulators and biological characterization using transcriptomes
Kikuchi, N., Matsusaka, H., Bai, L., Sano, H., Eitsuka, T., Nakagawa, K., Sugano, E., Ozaki, T., Tomita, H., Kiyono, T., Fukuda, T.*
Cell Biol. Int. (2023).
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The difference in the cellular uptake of tocopherol and tocotrienol is influenced by their affinities to albumin
Nakatomi, T., Itaya-Takahashi, M., Horikoshi, Y., Shimizu, N., Parida, I.S., Jutanom, M., Eitsuka, T., Tanaka, Y., Zingg, J.-M., Matsura, T., Nakagawa K.*
Sci. Rep. 13, 7392 (2023).
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Expression and functional analyses for estrogen receptor and estrogen related receptor of Yesso scallop, Patinopecten yessoensis
Gu, W., Thitiphuree, T., Otoki, Y., Marquez, E.C., Kitano, T., Itoh, N., Nagasawa, K., Osada, M.
J. Steroid Biochem. Mol., 106302 (2023).
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Immortalization of primary cells derived from the endangered Ryukyu long-furred rat
Bai, L., Kikuchi, N., Eitsuka, T., Matsusaka, H., Nakagawa, K., Katayama, M., Ito, K., Inoue-Murayama, M., Kiyono,T., Fukuda, T.*
In Vitro Cellular & Developmental Biology - Animal 59, 224-233 (2023).
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コーヒーシルバースキンに含まれる3-ピリジノールの単離精製とメラニン産生に及ぼす影響
渡辺章夫, 衛藤未侑, 小山彩華, 要害心, 保永陽依, 前原一葉, 宮本京香, 加藤毅, 三嶋隆, 仲川清隆
十文字大学紀要 53, 29-36 (2023).
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Quantitative lipidomic analysis of serum phospholipids reveals dissociable markers of Alzheimer disease and subcortical cerebrovascular disease
Otoki, Y., Yu, D., Shen, Q., Sahlas, D.J., Ramirez, J., Gao, F., Masellis, M., Swartz, R.H., Chan, P.C., Pettersen, J.A., Kato, S., Nakagawa, K., Black, S.E., Swardfager, W., Taha, A.T.*
J. Alzheimer's Dis. 93, 665-682 (2023).
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Effects of particle size of curcumin solid dispersions on bioavailability and anti-inflammatory activities
Kato, C., Itaya-Takahashi, M., Miyazawa, T., Ito, J., Parida, I.S., Yamada, H., Abe, A., Shibata, M., Someya, K., Nakagawa,K.*
Antioxidants 12, 724 (2023).
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Elucidation of decomposition pathways of linoleic acid hydroperoxide isomers by GC-MS and LC-MS/MS
Miyazaki, R., Kato, S., Otoki, Y., Rahmania, H., Sakaino, M., Takeuchi, S., Sato, T., Imagi, J., Nakagawa, K.*
Biosci. Biotechnol. Biochem. 87, 179-190 (2023).
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Clinical evaluation based on a new approach to improve the accuracy of 4β-hydroxycholesterol measurement as a biomarker of CYP3A4 activity
Taya, Y. Mizunaga, M., Nakao, S., Jutanom, M., Shimizu, N., Nomura, Y., Nakagawa,K.*
Molecules 28, 1576 (2023).
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レビュー・書籍・プレス・その他
国内学会（招待講演、等）
国内学会（一般講演）
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アゼライン酸を含むトリグリセリドの生成に関する研究
境野眞善, 加藤俊治, 佐野貴士, 青木亮輔, 清水直紀, 伊藤準哉, 今義潤, 齋藤三四郎, 佐藤俊郎, 仲川清隆
日本農芸化学会2023年度大会（広島・Web, 2023/3/14-17）
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コーヒーシルバースキン由来3-ピリジノールのメラニン産生促進効果
宮本京香, 衛藤未侑, 小山彩華, 要害心, 保永陽依, 前原一葉, 小林亘, 加藤毅, 三嶋隆, 仲川清隆, 渡辺章夫
日本食品科学工学会 第70回記念大会（京都, 2023/8/24-26）
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国際学会（招待講演、等）
国際学会（一般講演）
2022年
受賞
学術論文
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Evidence of increased sequestration of pro-resolving lipid mediators within brain esterified lipid pools of multiple sclerosis patients
Shen, Q., Otoki, Y., Sobel, R.A., Nagra, R.M., Taha, A.Y.*
Mult . Scler. Relat. Disord. 68, 104236 (2022).
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Structural analysis and anti-inflammatory effect of a digalactosyldiacylglycerol-monoestolide, a characteristic glycolipid in oats
Yamada, H., Ito, J., Shimizu, N., Takahashi, T., Kato, C., Parida, I.S., Jutanom, M., Ishihara, K., Nakagawa,K.*
Nutrients 14, 4153 (2022).
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Coprinopsis cinerea dioxygenase is an oxygenase forming 10(S)-hydroperoxide of linoleic acid, essential for mushroom alcohol, 1-octen-3-ol synthesis
Teshima, T., Funai, R., Nakazawa, T., Ito, J., Utsumi, T., Kakumyan, P., Mukai, H., Yoshiga, T., Murakami, R., Nakagawa, K., Honda, Y., Matsui, K.*
J. Biol. Chem. 298, 102507 (2022).
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Dietary triacylglycerol hydroperoxide is not absorbed, yet it induces the formation of other triacylglycerol hydroperoxides in the gastrointestinal tract
Takahashi, T., Kato, S., Ito, J., Shimizu, N., Parida, I.S., Itaya-Takahashi, M., Sakaino, M., Imagi, J., Yoshinaga, K., Yoshinaga-Kiriake, A., Gotoh, N., Ikeda. I., Nakagawa, K.*
Redox. Biol. 57, 102471 (2022).
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Possible Glutathione Peroxidase 4-Independent Reduction of Phosphatidylcholine Hydroperoxide: Its Relevance to Ferroptosis
Kato, C., Suzuki, Y., Parida, I.S., Kato, S., Yamasaki, H., Takekoshi, S., Nakagawa, K.*
J. Oleo Sci. 71, 1689-1694 (2022).
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Cellular uptake of pyrroloquinoline quinone in its intact and derivatized forms from the cell culture medium of 3T3-L1
Kato, C., Parida, I.S., Maeda, S., Mikekado, T., Kato, S., Takekoshi, S., Nakagawa, K.*
J. Oleo Sci. 71, 1761-1767 (2022).
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A non-canonical vitamin K cycle is a potent ferroptosis suppressor
Mishima, E.*, Ito, J., Wu, Z., Nakamura, T., Wahida, A., Doll, S., Tonnus, W., Nepachalovich, P., Eggenhofer E., Aldrovandi, M., Henkelmann, B., Yamada, K., Wanninger, J., Zilka, O., Sato, E., Feederle, R., Hass, D., Maida, A., Mour_o, A.S.D., Linkermann, A., Geissler, E.K., Nakagawa, K., Abe, T., Fedorova, M., Proneth, B., Pratt, D.A., Conrad, M.*
Nature 608, 778-783 (2022).
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Determination of olive oil oxidation mechanisms by analysis of triacylglycerol hydroperoxide isomers using LC-MS/MS
Takahashi, H., Kato, S., Shimizu, N., Otoki, Y., Ito, J., Sakaino, M., Sano, T., Imagi, J., Nakagawa, K.*
Molecules 27, 5282 (2022).
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Carboxylic acids derived from triacylglycerols that contribute to the increase in acid value during the thermal oxidation of oils
Sakaino, M., Sano, T., Kato, S., Shimizu, N., Ito, J., Rahmania, H., Imagi, J., Nakagawa, K.*
Sci. Rep. 12, 12460 (2022).
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Improving water dispersibility and bioavailability of luteolin using microemulsion system
Miyashita, A., Ito, J., Parida, I.S., Syoji, N., Fujii, T., Takahashi, H., Nakagawa, K.*
Sci. Rep. 12, 11949 (2022).
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Immortalization of common marmoset-derived fibroblasts via expression of cell cycle regulators using the piggyBac transposon
Orimoto, A.*, Shinohara, H. Eitsuka, T., Nakagawa, K., Sasaki, E., Kiyono, T.*, Fukuda, T.*
Tissue Cell 77, 101848 (2022).
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Cellular concentrations of plasmalogen species containing a polyunsaturated fatty acid significantly increase under hypoxia in human colorectal cancer, Caco2 cells
Tamiya-Koizumi, K., Otoki, Y., Nakagawa, K., Kannagi, R., Mizutani, N., Suzuki, M., Kyogashima, M., Iwaki, S., Aoyama, M., Murate, T., Kitatani, K., Kuga, T., Mizutani, Y., Tokumura, A.*
Biochem. Biophys. Res. Commun. 611, 1-7 (2022).
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Effects of hypercapnia / ischemia and dissection on the rat brain metabolome
Sylvestre, D.A., Otoki, Y., Metherel, A.H., Bazinet, R.P., Slupsky, C.M. Taha. A.Y.*
Neurochem. Int. 156, 105294 (2022).
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Determination of acrolein generation pathways from linoleic acid and linolenic acid: increment by photo irradiation
Kato, S., Shimizu, N., Otoki, Y., Ito, J., Sakaino, M. Sano, T., Takeuchi, S., Imagi, J., Nakagawa, K.*
npj Sci. Food 6, 21 (2022).
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Lipidomics and redox lipidomics indicate early-stage alcohol-induced liver damage
Koelmel, J.P., Tan, W.Y., Li, Y., Bowden, J.A., Ahmadireskety, A., Patt, A.C., Orlicky, D.J., Math_, E., Kroeger, N.M., Thompson, D.C., Cochran, J.A., Golla, J.P., Kandyliari, A., Chen, Y., Charkoftaki, G., Guingab-Cagmat, J.D., Tsugawa, H., Arora, A., Veselkov, K., Kato, S., Otoki, Y., Nakagawa, K., Yost, R.A., Garrett, T.J.*, Vasilou, V.*
Hepatol. Commun. 6, 513-525 (2022).
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レビュー・書籍・プレス・その他
国内学会（招待講演、等）
国内学会（一般講演）
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ヒトとラットで茶カテキン立体異性体の体内挙動は異なる
宮下采夏, 伊藤隼哉, 庄子真樹, 荒木義晴, 常深秀人, 麻生賢太, 小林誠, 瀧原孝宣, 衣笠仁, 〇仲川清隆
日本ビタミン学会第74回大会（福岡, 2022/6/26）
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国際学会（招待講演、等）
国際学会（一般講演）
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Discovery of novel human metabolites, dimethylated rosmarinic acids (DiMe-RAs), after oral intake of Perilla frutescens purpurea extract and their inhibitory activity on TRPV4
Akihiro Takamura, Masazumi Iwashita, Eri Ozeki, Kohjiro Hashizume, Ryuta Shioi, Naoya Kitamura, Akihiro Fujii, Takatoshi Murase, Kiyotaka Nakagawa
22nd IUNS-International Congress of Nutrition（Tokyo, 2022/12/6-11）
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