研究業績
2025年
受賞
学術論文
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Elucidating the antioxidative mechanisms by blending rice bran oil with canola oil at ambient temperatureKoishi, S., Honda, S., Matsuki, M., Sawada, K., Hashimoto, H., Kadono, Y., Rahmania, H., Otoki, Y., Kato, S., & Nakagawa, K.*Food Res. Int., 221, 4, 117509 (2025).Effects of sodium chloride on the formation of 3-Monochloropropanediol esters in various meats and health risk assessmentHao-Ting Chen, Chui Xuan Tan, Jiun-Rong Chen, Kiyotaka Nakagawa, Shunji Kato, Wei-Ju LeeFood Chemistry: X, 29, 102754 (2025).Synthesis of Citrifurans A and D through Assembly of the Natural Products Citrinin and Gregatin AGoto, Y., Machiya, A., Okumura, T., Oka, Y., Ito, J., Ishibashi, O., Shiono, Y., Meguro, Y., Nakagawa, K., Kuwahara, S., Enomoto, M.*Org. Lett., 27, 30, 8349-8352 (2025).MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4Mishima, E.#, O'Neill, T.J.#, Hoefig, K.P., Chen, D., Behrens, G., Henkelmann, B., Ito, J., Nakagawa, K., Heissmeyer, V.*, Conrad, M.*, Krappmann, D.*Proc. Natl. Acad. Sci. U.S.A., 122, e2507997122 (2025).N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4Zheng, J., Zhang, W., Ito, J., Henkelmann, B., Xu, C., Mishima, E., Conrad, M.*Cell Chem. Biol., 32, 767-775 (2025).Relationship between the Particle Size and the Oxidative Stability of Aqueous Emulsion Prepared from Triacylglycerol Rich in Docosahexaenoic AcidSato-Ishizaki, Y.*, Iguchi, A., Someya, K., Kusumoto, I., Kato, S., Nakagawa, K., Gotoh, N.J. Oleo Sci., 74, 8, 729-737 (2025).Air pollution and Alzheimer disease phenotype deplete esterified pro-resolving lipid mediator reserves in the brainTaha, A. Y.*, Shen, Q., Otoki, Y., Liang, N., Patten, K. T., Valenzuela, A. E., Wallis, C. D., Rowland, D. J., Chaudhari, A. J., Bein, K. J., Wexler, A. S., Jin, L.-W., Dugger, B. N., Harvey, D. J., Lein, P. J.JCI Insight., e175917 (2025).The Therapeutic Potential of Plant-Derived Flavonoids in Neurological Disorders Through Modulation of Brain Insulin SignalingParida, I.S., Rahmania, H., Nakagawa, K.*Food Sci. Technol. Res., 31, 75-89 (2025).Nondestructive determination of canola oil oxidation causes: A near-infrared spectroscopy coupled with liquid chromatography-mass spectrometry for analyzing triacylglycerol hydroperoxide isomersOtoki, Y.*, Ishikawa, D., Kato, S., Kusumoto, I., Ozaki, Y., Nakagawa, K.*Food Chem., 467, 142143 (2025).Effect of microemulsion system on water dispersibility and bioavailability of γ-oryzanolIto, J., Kumagai, N., Suzuki, A., Shoji, N., Parida, I. S., Takahashi, M., Nakagawa, K.*Biosci. Biotechnol. Biochem., 89, 633–637 (2025).Dietary Ethanolamine Plasmalogen from Ascidian Alleviates Chronic Hepatic Injury in Mice Treated with Continuous AcetaminophenSogame, R., Tominaga, Y., Echigoya, M., Nakagawa, K., Fukushima, M., Miyazawa, T., Kinoshita, M., Yamashita, S.*Appl. Sci., 15, 5968 (2025).
レビュー・書籍・プレス・その他
国内学会（招待講演、等）
国内学会（一般講演）
国際学会（招待講演、等）
国際学会（一般講演）
2024年
受賞
学術論文
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Impact of selenium content in fetal bovine serum on ferroptosis susceptibility and selenoprotein expression in cultured cellsTakashima, H., Toyama, T.*, Mishima, E., Ishida, K., Wang, Y., Ichikawa, A., Ito, J., Yogiashi, S., Siu, S., Sugawara, M., Shiina, S., Arisawa, K., Conrad, M., Saito, S.*J. Toxicol. Sci., 49, 555-563 (2024).Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondriaHirata Y*, Yamada Y, Taguchi S, Kojima R, Masumoto H, Kimura S, Niijima T, Toyama T, Kise R, Sato E, Uchida Y, Ito J, Nakagawa K, Taguchi T, Inoue A, Saito Y, Noguchi T, Matsuzawa A.*Cell Death Dis., 15, 884 (2024).PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilizationIto, J., Nakamura, T., Toyama, T., Chen, D., Berndt, C., Poschmann, G., Mour_o, A. S. D., Doll, S, Suzuki, M., Zhang, W., Zheng, J., Tr_mbach, D., Yamada, N., Ono, K., Yazaki, M., Kawai, Y., Arisawa, M., Ohsaki, Y., Shirakawa, H., Wahida, A., Proneth, B., Saito, Y., Nakagawa, K., Mishima, E., Conrad, M.Mol. Cell., 84, 4629-4644 (2024).Oil polyunsaturated fatty acid composition but not tocopherol levels determine oxylipin formation in plant and algae oils during pan-fryingKusumoto, I., Hennebelle, M., Crawford, L. M., Wang, S. C., Taha, A. Y.*J. Food Compos. Anal., 136, 106739 (2024).Mechanism of lipid peroxidation of liposomes by cold atmospheric pressure plasma jet irradiationTakajo, T., Saito, K., Tsuchida, K., Kato, S., Nakagawa, K., Okino, A., Anzai, K.*J. Clin. Biochem. Nutr., 75, 183-189 (2024).1-Deoxynojirimycin attenuates pathological markers of Alzheimer's disease in the in vitro model of neuronal insulin resistanceParida, I.S., Takasu, S., Ito, J., Eitsuka, T., Nakagawa, K.*FASEB J., 15, e23800 (2024).Effects of different manufacturing processes on thermal and photo-oxidative stability of sesame oilRahmania, H.#, Nakanishi, T.#, Oi, S., Onishi, R., Yamagami, E., Yamane,K., Otoki, Y., Kato, S., Nakagawa, K.*J. Oleo Sci., 73, 1267-1276 (2024).Intraperitoneally injected d11-11(12)-epoxyeicosatrienoic acid is rapidly incorporated and esterified within rat plasma and peripheral tissues but not the brainWatanabe, S., Souza, F. D. C., Kusumoto, I., Shen, Q., Nitin, N., Lein, P. J., Taha, A. Y.Prostaglandins, Leukot. Essent. Fat. Acids, 102622 (2024).Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesisYamada, N.#*, Karasawa, T.#*, Ito, J., Yamamuro, D., Morimoto, K., Nakamura, T., Komada, T., Baatarjav, C., Saimoto, Y., Jinnouchi, Y., Watanabe, K., Miura, K., Yahagi, Y., Nakagawa, K., Matsumura, T., Yamada, K., Ishibashi, S., Sata, N., Conrad M., Takahashi, M.*Nat. Commun., 15, 2195 (2024).A tangible method to assess native ferroptosis suppressor activityNakamura, T.#, Ito, J.#, Mour_o, A.S.D., Wahida, A., Nakagawa, K., Mishima, E.*, Conrad, M.*Cell Rep. Methods, 4, 100710 (2024).Identification of genes associated with resistance to persulcatusin, a tick defensin from Ixodes persulcatusShimoda, S., Ito, J., Ando, T., Tobe, R., Nakagawa, K., Yoneyama, H.*Microorganisms, 12, 412 (2024).Induction of ferroptosis in human keratinocyte HaCaT cells by squalene hydroperoxide: Possible prevention of skin ferroptosis by botanical extractsKato, C., Kusumoto, I., Kato, S., Otoki, Y., Ito, J., Totsuka, H., Rajgopal, A., Hong, J., Nakagawa, K.*Biochem. Biophys. Res. Commun., 698, 149553 (2024).Comparison of the catabolic rates of linoleic and oleic acid hydroperoxides using 13CO2 expired from miceYoshinaga-Kiriake, A., Miyagawa, S., Yoshino, K., Tanaka, S., Yoshinaga, K., Takahashi, T., Kato, S., Ito, J., Yurika, O., Nakagawa, K., Gotoh, N.*J. Oleo Sci. (2024).Preparation of saturated fatty acid hydroperoxide isomers and determination of their thermal decomposition products _ 2-alkanones and lactonesAoyagi, K., Kato, S., Isaka, D., Sekiguchi, Y., Otoki, Y., Uehara, H., Nakagawa, K.*Food Chem. X, 21, 101074 (2024).Higher Cholesterol Absorption Marker at Baseline Predicts Fewer Cardiovascular Events in Elderly Patients Receiving Hypercholesterolemia Treatment: The Kyushu Elderly Ezetimibe Phytosterol (KEEP) StudyKuwabara, M., Sasaki, J., Ouchi, Y., Oikawa, S., Nakagawa, K., Sato, M., Koba, S., Kono, S., Saikawa, T., Arai, H.*J. Am. Heart Assoc., 13, e03165 (2024).LC-MS/MS analysis of milk triacylglycerol hydroperoxide isomers which are generated corresponding to the photo- and thermal-oxidationSaito, H., Kato, S., Shimizu, N., Takahashi, T., Jutanom, M., Ito, J., Kasatani, S., Nakagawa, K.*Food Res. Int., 178, 113913 (2024).
レビュー・書籍・プレス・その他
国内学会（招待講演、等）
国内学会（一般講演）
国際学会（招待講演、等）
国際学会（一般講演）
2023年
受賞
学術論文
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Analysis of oxidized glucosylceramide and its effects on altering gene expressions of inflammation induced by LPS in intestinal tract cell modelsJutanom, M., Kato, S., Yamashita, S., Toda, M., Kinoshita, M., Nakagawa, K.*Sci. Rep., 13, 22537 (2023).Unveiling an unexpected superoxide-mediated photooxidation mechanism of squalene monohydroperoxides to squalene hydroperoxy cyclic peroxides through ESR and LC_MS/MS analysesKhalifa, S., Enomoto, M., Nakagawa, K.*Sci. Rep., 13, 19525 (2023).Sheep-derived cell immortalization through the expression of cell cycle regulators and biological characterization using transcriptomesKikuchi, N., Matsusaka, H., Bai, L., Sano, H., Eitsuka, T., Nakagawa, K., Sugano, E., Ozaki, T., Tomita, H., Kiyono, T., Fukuda, T.*Cell Biol. Int. (2023).The difference in the cellular uptake of tocopherol and tocotrienol is influenced by their affinities to albuminNakatomi, T., Itaya-Takahashi, M., Horikoshi, Y., Shimizu, N., Parida, I.S., Jutanom, M., Eitsuka, T., Tanaka, Y., Zingg, J.-M., Matsura, T., Nakagawa K.*Sci. Rep., 13, 7392 (2023).Expression and functional analyses for estrogen receptor and estrogen related receptor of Yesso scallop, Patinopecten yessoensisGu, W., Thitiphuree, T., Otoki, Y., Marquez, E.C., Kitano, T., Itoh, N., Nagasawa, K., Osada, M.J. Steroid Biochem. Mol., 106302 (2023).Immortalization of primary cells derived from the endangered Ryukyu long-furred ratBai, L., Kikuchi, N., Eitsuka, T., Matsusaka, H., Nakagawa, K., Katayama, M., Ito, K., Inoue-Murayama, M., Kiyono,T., Fukuda, T.*In Vitro Cellular & Developmental Biology - Animal, 59, 224-233 (2023).ホヤ由来エタノールアミン型プラズマローゲンの認知機能に対する有効性及び安全性評価―プラセボ対照ランダム化二重盲検並行群間比較―山本采佳*, 相澤光輝, 久保村大樹, 赤堀雄介, 山下慎司, 仲川清隆, 宮澤陽夫応用薬理, 104, 17-24 (2023).コーヒーシルバースキンに含まれる3-ピリジノールの単離精製とメラニン産生に及ぼす影響渡辺章夫, 衛藤未侑, 小山彩華, 要害心, 保永陽依, 前原一葉, 宮本京香, 加藤毅, 三嶋隆, 仲川清隆十文字大学紀要, 53, 29-36 (2023).Quantitative lipidomic analysis of serum phospholipids reveals dissociable markers of Alzheimer disease and subcortical cerebrovascular diseaseOtoki, Y., Yu, D., Shen, Q., Sahlas, D.J., Ramirez, J., Gao, F., Masellis, M., Swartz, R.H., Chan, P.C., Pettersen, J.A., Kato, S., Nakagawa, K., Black, S.E., Swardfager, W., Taha, A.T.*J. Alzheimer's Dis., 93, 665-682 (2023).Effects of particle size of curcumin solid dispersions on bioavailability and anti-inflammatory activitiesKato, C., Itaya-Takahashi, M., Miyazawa, T., Ito, J., Parida, I.S., Yamada, H., Abe, A., Shibata, M., Someya, K., Nakagawa,K.*Antioxidants, 12, 724 (2023).Elucidation of decomposition pathways of linoleic acid hydroperoxide isomers by GC-MS and LC-MS/MSMiyazaki, R., Kato, S., Otoki, Y., Rahmania, H., Sakaino, M., Takeuchi, S., Sato, T., Imagi, J., Nakagawa, K.*Biosci. Biotechnol. Biochem., 87, 179-190 (2023).Clinical evaluation based on a new approach to improve the accuracy of 4β-hydroxycholesterol measurement as a biomarker of CYP3A4 activityTaya, Y. Mizunaga, M., Nakao, S., Jutanom, M., Shimizu, N., Nomura, Y., Nakagawa,K.*Molecules, 28, 1576 (2023).Analysis of docosahexaenoic acid hydroperoxide isomers in mackerel using liquid chromatography_mass spectrometryKusumoto, I., Kato, S., Nakagawa, K.*Sci. Rep., 13, 1325 (2023).
レビュー・書籍・プレス・その他
国内学会（招待講演、等）
国内学会（一般講演）
国際学会（招待講演、等）
国際学会（一般講演）
2022年
受賞
学術論文
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Evidence of increased sequestration of pro-resolving lipid mediators within brain esterified lipid pools of multiple sclerosis patientsShen, Q., Otoki, Y., Sobel, R.A., Nagra, R.M., Taha, A.Y.*Mult . Scler. Relat. Disord., 68, 104236 (2022).Structural analysis and anti-inflammatory effect of a digalactosyldiacylglycerol-monoestolide, a characteristic glycolipid in oatsYamada, H., Ito, J., Shimizu, N., Takahashi, T., Kato, C., Parida, I.S., Jutanom, M., Ishihara, K., Nakagawa,K.*Nutrients, 14, 4153 (2022).Coprinopsis cinerea dioxygenase is an oxygenase forming 10(S)-hydroperoxide of linoleic acid, essential for mushroom alcohol, 1-octen-3-ol synthesisTeshima, T., Funai, R., Nakazawa, T., Ito, J., Utsumi, T., Kakumyan, P., Mukai, H., Yoshiga, T., Murakami, R., Nakagawa, K., Honda, Y., Matsui, K.*J. Biol. Chem., 298, 102507 (2022).Dietary triacylglycerol hydroperoxide is not absorbed, yet it induces the formation of other triacylglycerol hydroperoxides in the gastrointestinal tractTakahashi, T., Kato, S., Ito, J., Shimizu, N., Parida, I.S., Itaya-Takahashi, M., Sakaino, M., Imagi, J., Yoshinaga, K., Yoshinaga-Kiriake, A., Gotoh, N., Ikeda. I., Nakagawa, K.*Redox. Biol., 57, 102471 (2022).Possible Glutathione Peroxidase 4-Independent Reduction of Phosphatidylcholine Hydroperoxide: Its Relevance to FerroptosisKato, C., Suzuki, Y., Parida, I.S., Kato, S., Yamasaki, H., Takekoshi, S., Nakagawa, K.*J. Oleo Sci., 71, 1689-1694 (2022).Cellular uptake of pyrroloquinoline quinone in its intact and derivatized forms from the cell culture medium of 3T3-L1Kato, C., Parida, I.S., Maeda, S., Mikekado, T., Kato, S., Takekoshi, S., Nakagawa, K.*J. Oleo Sci., 71, 1761-1767 (2022).A non-canonical vitamin K cycle is a potent ferroptosis suppressorMishima, E.*, Ito, J., Wu, Z., Nakamura, T., Wahida, A., Doll, S., Tonnus, W., Nepachalovich, P., Eggenhofer E., Aldrovandi, M., Henkelmann, B., Yamada, K., Wanninger, J., Zilka, O., Sato, E., Feederle, R., Hass, D., Maida, A., Mour_o, A.S.D., Linkermann, A., Geissler, E.K., Nakagawa, K., Abe, T., Fedorova, M., Proneth, B., Pratt, D.A., Conrad, M.*Nature, 608, 778-783 (2022).Determination of olive oil oxidation mechanisms by analysis of triacylglycerol hydroperoxide isomers using LC-MS/MSTakahashi, H., Kato, S., Shimizu, N., Otoki, Y., Ito, J., Sakaino, M., Sano, T., Imagi, J., Nakagawa, K.*Molecules, 27, 5282 (2022).Carboxylic acids derived from triacylglycerols that contribute to the increase in acid value during the thermal oxidation of oilsSakaino, M., Sano, T., Kato, S., Shimizu, N., Ito, J., Rahmania, H., Imagi, J., Nakagawa, K.*Sci. Rep., 12, 12460 (2022).Total synthesis of the broad-spectrum antibiotic amycolamicinMeguro, Y., Ito, J., Nakagawa, K., Kuwahara, S.*J. Am. Chem. Soc., 144, 5253-5257 (2022).Improving water dispersibility and bioavailability of luteolin using microemulsion systemMiyashita, A., Ito, J., Parida, I.S., Syoji, N., Fujii, T., Takahashi, H., Nakagawa, K.*Sci. Rep., 12, 11949 (2022).Immortalization of common marmoset-derived fibroblasts via expression of cell cycle regulators using the piggyBac transposonOrimoto, A.*, Shinohara, H. Eitsuka, T., Nakagawa, K., Sasaki, E., Kiyono, T.*, Fukuda, T.*Tissue Cell, 77, 101848 (2022).Cellular concentrations of plasmalogen species containing a polyunsaturated fatty acid significantly increase under hypoxia in human colorectal cancer, Caco2 cellsTamiya-Koizumi, K., Otoki, Y., Nakagawa, K., Kannagi, R., Mizutani, N., Suzuki, M., Kyogashima, M., Iwaki, S., Aoyama, M., Murate, T., Kitatani, K., Kuga, T., Mizutani, Y., Tokumura, A.*Biochem. Biophys. Res. Commun., 611, 1-7 (2022).Effects of hypercapnia / ischemia and dissection on the rat brain metabolomeSylvestre, D.A., Otoki, Y., Metherel, A.H., Bazinet, R.P., Slupsky, C.M. Taha. A.Y.*Neurochem. Int., 156, 105294 (2022).Determination of acrolein generation pathways from linoleic acid and linolenic acid: increment by photo irradiationKato, S., Shimizu, N., Otoki, Y., Ito, J., Sakaino, M. Sano, T., Takeuchi, S., Imagi, J., Nakagawa, K.*npj Sci. Food, 6, 21 (2022).Lipidomics and redox lipidomics indicate early-stage alcohol-induced liver damageKoelmel, J.P., Tan, W.Y., Li, Y., Bowden, J.A., Ahmadireskety, A., Patt, A.C., Orlicky, D.J., Math_, E., Kroeger, N.M., Thompson, D.C., Cochran, J.A., Golla, J.P., Kandyliari, A., Chen, Y., Charkoftaki, G., Guingab-Cagmat, J.D., Tsugawa, H., Arora, A., Veselkov, K., Kato, S., Otoki, Y., Nakagawa, K., Yost, R.A., Garrett, T.J.*, Vasilou, V.*Hepatol. Commun., 6, 513-525 (2022).